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Steven J. Miller, PhD

Associate Professor of Surgery
Associate Professor of Cellular and Integrative Physiology

Specialty: Vascular Surgery

 

Steven J. Miller, Ph.D., joined the faculty at the Indiana University School of Medicine in July of 2004, where he is an Associate Professor of Surgery in the Division of Vascular Surgery, with an adjunct appointment in the Department of Cellular and Integrative Physiology.  He received his Ph.D. from the Indiana University Department of Biochemistry, and completed a Postdoctoral Fellowship under Dr. Nils Bang in the Department of Medicine.  Dr. Miller came to IU after 10 years at Methodist Hospital where he began as an Assistant Scientist in Reproductive and Transplantation Immunology and later became an Associate Investigator in the Methodist Research Institute (MRI).  Dr. Miller’s research interests while at MRI were focused on transplant vasculopathy, specifically the role of glycosaminoglycans and antithrombin in endothelial dysfunction and resultant microinfarctions due to fibrin deposition.  He has served as principal or co-principal investigator on over 18 research projects, most recently as the PI on an NIH R01 award, and has more than 30 peer-reviewed publications and over 80 abstracts.  His teaching experience over the last 20 years includes mentoring undergraduate, graduate, and medical students as well as surgery residents, and he has served as research advisor for two postdoctoral fellows in addition to providing lectures on vascular physiology for two courses.  He also has participated in the national SEED program for high school students, hosted by the American Chemical Society, and the Frontiers in Physiology program for high school science teachers sponsored by the American Physiological Society.  Dr. Miller currently is the director for the Problem Based Learning portion of the IU Master of Science in Medical Science Program. His current research interests are focused on studying the mechanisms responsible for impaired compensatory flow-mediated remodeling of the peripheral vasculature in the context of risk factors that include aging, obesity, and hypertension.

Clinical Research Interests: Evaluating metabolic markers associated with imparied collateral growth in patients with peripheral vascular disease.
Basic Research Interests: My studies are currently focused on investigating mechanisms that regulate pathological and compensatory vascular remodeling during aging.

Publications

  1. Labarrere, C.A., Nelson, D.R., Miller, S.J., Nieto, J.M., Conner, J.A., Pitts, D.E., Kirlin, P.C. and Halbrook, H.G.  Value of serum soluble intercellular adhesion molecule-1 for the noninvasive risk assessment of transplant coronary artery disease, posttransplant ischemic events, and cardiac graft failure.  Circulation 102: 1549-1555, 2000.
  2. Torry, R.J., Bai, L., Miller, S.J., Labarrere, C.A., Nelson, D.R. and Torry, D.S.  Increased vascular endothelial growth factor expression in human hearts with microvascular fibrin.  J. Mol. Cell. Cardiol. 33: 175-184, 2001.
  3. Labarrere, C.A., Torry, R.J.,  Nelson, D.R., Miller, S.J., Pitts, D.E., Kirlin, P.C. and Halbrook,  H. Vascular antithrombin and clinical outcome in heart transplant patients.  Am. J. Cardiol. 87: 425-431, 2001.
  4. Tuttle, J.L., Hahn, T.L., Sanders, B.M., Witzmann, F.A., Miller, S.J., Dalsing, M.C. and Unthank, J.L.  Impaired collateral development in mature rats. Am. J. Physiol. (Heart) 283: H146-H155, 2002.
  5. Labarrere, C.A., Lee, J.B., Nelson, D.R., Al-Hassani, M., Miller, S.J. and Pitts, D.E.  C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: a prospective study.  Lancet 360: 1462-1467, 2002.
  6. Miller, S.J.  Cellular and physiologic effects of short chain fatty acids.  Mini-Reviews  in Medicinal Chemistry 4:839-845, 2004.
  7. Miller, S.J., Zaloga, G., Hoggatt, A., Labarrere, C.A., and Faulk, W.P.  Short chain fatty acids modulate gene expression for vascular endothelial adhesion molecules.  Nutrition 21: 740-748, 2005.
  8. Payner, T., Leaver, H.A., Knapp, B., Whittle, I.R., Trifan, O.C., Miller, S., and Rizzo, M.T. Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E2-dependent activation of type II protein kinase A.  Molecular Cancer Therapeutics 5(7): 1817-1826, 2006.
  9. Miller, S.J., Norton, L.E., Murphy, M.P., Dalsing, M.C., and Unthank, J.L.  The role of the renin-angiotensin system and oxidative stress in spontaneously hypertensive rat mesenteric collateral growth impairment.  Am. J. Physiol. Heart Circ. Physiol. 292: H2523-H2531, 2007.
  10. Miller, S.J., Watson, W.C., Kerr, K.A., Labarrere, C.A., Chen, N.X., Deeg, M.A., and Unthank, J.L.  Development of progressive aortic vasculopathy in a rat model of aging. Am. J. Physiol. Heart Circ. Physiol. 293: H2634-H2643, 2007.
  11. Sheridan, K.M., Ferguson, M.J., DiStasi, M.R., Witzmann, F.A., Miller, S.J., and Unthank, J.L.  Impact of genetic background and aging on mesenteric collateral growth capacity in F344, BN, and F344xBN rats. Am. J. Physiol. Heart Circ. Physiol. 293: H3498-H3505, 2007.
  12. Harvey, K.A., Arnold, T., Rasool, T., Antalis, C., Miller, S.J., and Siddiqui, R.A.  Trans-fatty acids induce pro-inflammatory responses and endothelial cell dysfunction. British J. Nutrition 99: 723-731, 2008.
  13. Zhou, X., Bohlen, H.G., Miller, S.J., and Unthank, J.L.  NAD(P)H oxidase-derived peroxide mediates elevated basal and impaired flow-induced NO production in SHR mesenteric arteries in vivo. Am. J. Physiol. Heart Circ. Physiol. 295: H1008-H1016, 2008.
  14. Richardson, M.R., Lai, X., Mason, S.B., Miller S.J., and Witzmann, F.A.  Differential protein expression during aging in ventricular myocardium of Fischer 344 X Brown Norway hybrid rats. Exp. Gerontol. 43: 909-918, 2008.
  15. Torry, R.J., Tomanek, R.J., Zheng, W., Miller, S.J., Labarrere, C.A., and Torry, D.S.  Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes.  J Heart Lung Transplantation 28: 183-190, 2009.
  16. DiStasi, M., Case, J., Ziegler, M., Dinauer, M., Yoder, M., Haneline, L., Dalsing, M., Miller, S.J., Murphy, M., Ingram, D., and Unthank, J.L.  Suppressed Hindlimb Perfusion in Rac2-/- and Nox2-/- Mice Does Not Result from Impaired Collateral Growth. Am. J. Physiol. Heart Circ. Physiol. 296: H877-H886, 2009.
  17. Siddiqui, R.A., Harvey, K.A., Ruzmetov, N., Miller, S.J., and Zaloga, G.P.  Omega-3 fatty acids prevent whereas Trans fatty acids induce vascular inflammation and sudden cardiac death.  Brit. J. Nutrition 102: 1811-1819, 2009.
  18. Bohlen, H.G., Zhou, X., Unthank, J.L., Miller, S.J., and Bills, R.  Transfer of nitric oxide by blood from upstream to downstream resistance vessels causes microvascular dilation.  Am. J. Physiol. Heart Circ. Physiol. 297: H1337-H1346, 2009.
  19. Zhou, X., Bohlen, H.G., Unthank, J.L., and Miller, S.J.  Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide. Am. J. Physiol. Heart Circ. Physiol. 297: H2227-H2233, 2009.
  20. Miller, S.J., Coppinger, B.J., Zhou, X., and Unthank, J.L.  Antioxidants reverse age-related collateral growth impairment. J. Vasc. Res. 47: 108-114, 2010.
  21. Ziegler, M.A., DiStasi, M.R., Bills, R.G., Miller, S.J., Alloosh, M., Murphy, M.P., Akingba, G., Sturek, M., Dalsing, M.C., and Unthank, J.L.  Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusion.  Microcirculation 17: 3-20, 2010.
  22. Unthank JL, McClintick JN, Labarrere CA, Li L, DiStasi MR, and Miller SJ.  Molecular basis for impaired collateral artery growth in the Spontaneously Hypertensive Rat:  Insight from microarray analysis.  Physiol Rep, 1 (2): e0005, DOI:10.1002/phy2.5, 2013.
  23. Berwick ZC, Dick GM, O’Leary HA, Bender SB, Goodwill AG, Moberly SP, Owen MK, Miller SJ, Obukhov AG, Tune JD.  Contribution of electromechanical coupling between KV and Ca­V1.2 channels to coronary dysfunction in obesity.  Basic Res Cardiol 108:370-382, 2013.
  24. DiStasi MR, Unthank JL, and Miller SJ.  Nox2 and p47phox modulate compensatory growth of primary collateral vessels.  Am J Physiol Heart Circ Physiol 306:H1435-H1443, 2014.

Department of Surgery | 545 Barnhill Drive, Emerson Hall 203, Indianapolis, In 46202 | Phone: (317) 274-5771