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Ping Li, PhD

Assistant Professor of Surgery

Basic Research Interests:

Antibody-mediated rejection and interspecies immunological incompatibility are major barriers to xenotransplantation. Our goal is to generate genetically modified pig organs for xenotransplantation. We focus on removing xenoantigens from pig tissues as well as making transgenic pigs in order to achieve graft survival.

 

We have successfully used cutting-edge technologies such as Zinc Finger Nuclease (ZFN) and transcription activator-like effector nucleases (TALENs) to silence genes. Two major xenoantigens, a-Gal and Neu5GC, had been eliminated in pig tissues by the disruption of the α1,3-galactosyltransferase (GGTA1) gene and cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene.

 

Currently, we are working on knockout of asialoglycoprotein receptor 1 (ASGR1) gene as well as knock-in of human signal-regulatory protein alpha (SIRPA) gene in pigs. Both genes are related to thrombocytopenia. Meanwhile, we have cloned porcine ubiquitous promoter ROSA26 for transgenesis and identified porcine ROSA26 locus for gene targeting.

Please visit http://www.xenobridge.com for more information.

Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response.
Related Articles Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. Transpl Immunol. 2016 Mar;35:47-51 Authors: Butler JR, Wang ZY, Martens GR, Ladowski JM, Li …

 

Department of Surgery | 545 Barnhill Drive, Emerson Hall 203, Indianapolis, In 46202 | Phone: (317) 274-5771