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Jonathan Fridell, MD, FACS

Professor of Surgery
Chief, Division of Transplant Surgery
Director of Pancreas Transplantation
Chief Medical Officer, IU Health Transplant Institute

Specialty: Transplant Surgery - abdominal transplant surgery: pancreas, liver, intestine and kidney transplantation
Residency: McGill University (General Surgery)
Fellowship: Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center (Transplant Surgery)

Affiliations

IU Medical Group

Hospitals

IU Health Methodist/IU Health University

Location Information

IU Health Transplant

550 N University Blvd., Suite 4601

Indianapolis, IN 46202


Clinical Interests

Array


Accepting New Patients

Schedule an Appointment  Clinical Trials

Clinical Interests: pancreas transplantation

Clincal Research Interests: pancreas transplantation outcomes using expanded donors and in complicated recipients. Abdominal transplantation for cystic fibrosis

Publications

 

Teaching

 

  1. Fridell JA, Agarwal A, Powelson JA. “Pancreas Transplantation at Indiana University: A Brief Overview of Recent Progress”. In Corry, RJ and Shapiro, R. ed.  Pancreatic Transplantation.   Informa Healthcare USA, Inc, New York, 2007, 421-5.
  2.  Goggins W, Powelson JA, Fridell JA, Mishler D, Yaqub M, Chen J, Sharfuddin A, Taber T, Milgrom M.  Indiana University Kidney Transplant Program:  Overview and Summary of the last 1022 Kidney Alone Transplant with at least 1 year follow-up.  Clinical Transplants :135-42, 2009
  3.  Vianna, R, Kubal C, Mangus RS, Fridell JA, Tector, AJ.  Intestinal and Multivisceral transplantation at Indiana University:  6 years’ experience with 100 Cases.  Clinical Transplants :219-28, 2009
  4. Fridell JA, Rogers J, Stratta RJ. “Donor management and selection in pancreas transplantation”. In Hakim NS, Stratta RJ, Gray D, Friend P and Colman ed. Pancreas, islet and stem cell transplantation for diabetes second edition. Oxford University Press, 2010. 63-84
  5. Fridell, JA, Mangus, RS, Powelson JA, Mujtaba MA, Chen JM, Taber, TE. “Pancreas Transplantation in the New Millennium: the Indiana University Experience” In Cecka and Terasaki editors Clinical Transplants 2012

 

Service

 

  1.  Tector AJ, Fridell JA, Ruiz R, Khurana RJ, Jensen G, Mak A, Greinke D, Salazar J, Stevenson W, Metrakos P, Tchervenkov JI.  Experimental Discordant Hepatic Xenotransplantation in the Recipient with Liver Failure: Implications for Clinical Bridging Trials.  J Am Coll Surg. 2000 Jul; 191(1):54-64. 
  2. Tector AJ, Berho M, Fridell JA, DiCarlo A, Liu S, Soderland C, Barkun JS, Metrakos P, Tchervenkov JI.  Rejection of Pig Liver Xenografts in Patients with Liver Failure: Implication for Xenotransplantation.  Liver Transpl. 2001 Feb; 7(2):82-9. 
  3. Tector AJ, Fridell JA, Elias N, Watanabe T, Salazar J, Greinke D, Metrakos P, Tchervenkov JI. Aberrations in Hemostasis and Coagulation in Untreated Discordant Hepatic Xenotransplantation: Studies in the Dog-to-Pig Model.  Liver Transpl. 2002 Feb; 8(2):153-9 
  4. Jain AK, Venkartramanan R, Fridell JA, Gadomski M, Shaw LM, Ragni M, Korecka M, Fung JJ.  Nelfinavir a protease inhibitor, increases sirolimus levels in a liver transplant patient:  a case Report.  Liver Transpl. 2002 Sep; 8(9):838-40.
  5. Fridell JA, Jain A, Reyes J, Beiderman R, Green M, Sindhi R, Mazariegos G.  Causes of Mortality Beyond 1Year Following Pediatric Liver Transplant Under Tacrolimus.  Transplantation. 2002 Dec 27; 74(12):1721-4.
  6. Fridell JA, Jain A, Patel K, Fung J, Venkartramanan R.  Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report. The Drug Monit. 2003 Feb; 25(1):117-9.
  7. Fridell JA, Mazariegos G, Orenstein D, Sindhi R, Reyes J.  Liver and intestinal Transplantation in a Child with Cystic Fibrosis:  A Case Report.  Pediatric Transplant. 2003 Jun;7 (3):240-42
  8. Fridell JA, Bond GJ, Mazariegos G, Jain A, Orenstein D, Sindhi R, Finder J, Reyes J.  Liver Transplantation in Children with Cystic Fibrosis:  A Long-Term Longitudinal Review of a Single Center’s Experience.  J Pediatric Surg. 2003 Aug; 38(3):1152-56.
  9. Tector AJ, Fridell JA, Mangus RS, Shah A, Milgrom ML, Kwo P, Chalasani N, Yoo H, Rouch D, Liangpunsakul S, Herring S.  Promising early results with immunosuppression using rabbit anti-thymocyte globulin and steroids with delayed introduction of tacrolimus in adult liver transplant recipients.  Liver Transpl. 2004 Mar; 10 (3):404-7.
  10. Fridell JA, Milgrom ML, Henson S, Pescovitz MD.  Use of the end-to-end Anastomotic Circular Stapler for Creation of the Duodenoenterostomy for Enteric Drainage of the Pancreas Allograft.  J Am Coll Surgery. 2004 Mar; 198(3):495-7.
  11. Wheat LJ, Connolly P, Durkin M, Book BK, Tector AJ, Fridell JA, Pescovitz MD.  False-positive Histoplasma antigenemia caused by anti-thymocyte globulin antibodies. Transpl Infect Dis. 2004 Mar; 6(1):23-7.
  12. Fridell JA, Agarwal A, Milgrom ML, Murdock P, Pescovitz MD.  Comparison of Histidine-Tryptophan-Ketoglutarate (HTK) Solution and University of Wisconsin (UW) Solution for Organ Preservation in Clinical Pancreas Transplantation. Transplantation. 2004 April 27; 77 (8): 1304-6
  13. Fridell JA, Shah A. Milgrom ML, Goggins WC, Leapman SB, Pescovitz MD.  Ipsilateral placement of simultaneous pancreas and kidney allografts. Transplantation. 2004 Oct 15; 78(7):1074-6.
  14. Agarwal A, Goggins WC, Pescovitz MD, Milgrom ML, Murdock P, Fridell JA.  Comparison of Histidine-Tryptophan-Ketoglutarate and University of Wisconsin Solutions as primary preservation in renal allografts undergoing pulsatile perfusion. Transplant Proc. 2005 Jun; 37(5):2016-9.
  15. Agarwal A, Maglinte DD, Goggins WC, Pescovitz MD, Milgrom ML, Fridell JA.  Internal hernia after pancreas transplantation with enteric drainage: an unusual cause of small bowel obstruction.  Transplantation. 2005 Jul15;80(1):149-52.
  16. Vianna R, Giovanardi RO, Fridell JA, Tector AJ.   Multivisceral transplantation for diffuse portomesenteric thrombosis in a patient with life-threatening esophagogastroduodenal bleeding.  Transplantation. 2005 Aug 27; 80(4):534-5.
  17. Agarwal A, Milgrom ML, Goggins WC, Murdock P, Pescovitz MD, Fridell JA.  Follow-up Experience using histidine- tryptophan-ketoglutarate solution in clinical pancreas transplantation.  Transplant Proc. 2005 Oct; 37(8):3523-26.
  18. Fridell JA, Vianna R, Kwo PY, Howenstine M, Sannuti A, Molleston JP, Pescovitz MD, Tector AJ.  Simultaneous Liver and Pancreas Transplantation in Patients with Cystic Fibrosis.  Transplant Proc. 2005 Oct; 37(8):3567-69
  19. Mangus RS, Tector AJ, Agarwal A, Vianna R, Murdock P, Fridell JA.  Comparison of histidine-tryptophan-ketoglutarate solution (HTK) and University of Wisconsin solution in adult liver transplantation. Liver Transpl. 2006 Feb; 12(2):226-30.
  20. Agarwal A, Murdock P, Fridell JA.  Comparison of Histidine-Tryptophan-Ketoglutarate (HTK) Solution and University of Wisconsin (UW) solution in Prolonged Cold Preservation of Kidney Allografts. Transplantation. 2006 Feb15; 81(3):480-2.
  21. Alazmi WM, Fogel EL, Watkins JL, McHenry L, Tector AJ, Fridell J, Mosler P, Sherman S, Lehman GA. Recurrence Rate of Anastomotic Biliary Strictures in Patients who have had Previous Successful Endoscopic Therapy for Anastomotic Narrowing after Orthotopic Liver Transplantation. Endoscopy. 2006 Jun; 38(6):571-4.
  22. Shah A, Agarwal A, Mangus RS, Lim L, Molleston J, Vianna R, Fridell JA, Tector AJ. Induction Immunosuppression with Rabbit Antithymocyte Globulin in Pediatric Liver Transplantation. Liver Transpl. 2006 Jul 25; 12:1210-14.
  23. Fridell JA, Agarwal A, Goggins W, Powelson J, Milgrom M, Pescovitz MD.  Steroid Withdrawal for Pancreas after Kidney Transplantation in Recipients on Maintenance Prednisone Immunosuppression.  Transplantation. 2006 Aug 15; 82:389-92.
  24. Tector AJ, Mangus RS, Chestovich P, Vianna RM, Fridell JA, Milgrom ML, Sanders C, Kwo P. Use of extended criteria livers decreases wait time for liver transplantation without adversely impacting post transplant survival. Ann Surg. 2006 Sept; 244(3): 439-50.
  25. Lall C, Sandrasegaran K, Maglinte D, Fridell J. Bowel Complications Seen on CT After Pancreas Transplantation with Enteric Drainage. AJR Am J Roentgenol. 2006 Nov; 187(5):1288-95.
  26. Gage E, Jones GE, Powelson JA, Johnson MS, Goggins WC, Fridell JA. Treatment of enterocutaneous fistula in pancreas transplant recipients using percutaneous drainage and fibrin sealant: three cases. Transplantation. 2006 Nov 5; 82(9):1238-40.
  27. Fridell JA, Saxena R, Chalasani NP, Goggins WC, Powelson JA,  Cummings OW. Complete Reversal of Glycogen Hepatopathy with Pancreas Transplantation: Two Cases. Transplantation. 2007 Jan 15; 83(1):84-86.
  28. Vianna R, Misra V, Fridell JA, Goldman M, Mangus RS, Tector AJ. Survival after disseminated Invasive Aspergillosis in a Multivisceral Transplant Recipient. Transplant Proc. 2007 Jan – Feb; 39(1):305-7.
  29. Fridell JA, Gage E, Goggins, WC, Powelson JA.  Complex arterial reconstruction for pancreas transplantation in recipients with advanced arteriosclerosis.  Transplantation 2007 May 27; 83(10):1385-8.
  30. Mangus RS, Kinsella S, Nobari M, Fridell JA, Vianna RM, Ward ES, Tector AJ. Predictors of intraoperative blood product requirement in orthotopic liver transplantation using the piggyback hepatectomy technique. Transplant Proc. 2007 Dec; 39(10):3207-13.
  31. Mangus RS, Fridell JA, Vianna RM, Milgrom ML, Chestovich P, Chihara RK, Tector AJ. Comparison of Histidine-Tryptophan-Ketoglutarate solution and University of Wisconsin solution in extended criteria liver donors. Liver Transplant. 2008 Mar; 14(3):365-73.
  32. Fridell JA, Wozniak TC, Powelson JA, Reynolds JM. Simultaneous Bilateral Lung and Pancreas Transplantation in Recipient with Cystic Fibrosis. Transplant Proc. 2008 Mar; 40(2):494-7. PMID: 18374112
  33. Agarwal A, Powelson JA, Goggins WC, Milgrom ML, Fridell JA. Organ Preservation with Histidine-Tryptophan-Ketoglutarate Solution in Clinical Pancreas Transplantation: An Update of the Indiana University Experience. Transplant Proc. 2008 Mar; 40(2):498-501.
  34. Vianna RM, Mangus RS, Fridell JA, Weigman S, Kazimi M, Tector J. Induction Immunosuppression with Thymoglobulin and Rituximab in Intestinal and Multivisceral Transplantation. Transplantation. 2008 May 15; 85(9):1290-3.
  35. Mangus RS, Fridell JA, Vianna RM, Cooper AB, Jones DT, Tector AJ. Use of Piggyback Hepatectomy Technique in Liver Transplant Recipients with Hepatocellular Carcinoma. Transplantation. 2008 May 27; 85(10):1496-9.
  36. Vianna RM, Mangus RS, Fridell JA, Kazimi M, Hollinger E, Tector J. Initiation of an Intestinal Transplant Program: The Indiana Experience. Transplantation. 2008 June 27; 85(12):1784-90.
  37. Fridell JA, Wozniak TC, Reynolds JM, Powelson JA, Hollinger EF, Duncan MW, Sannuti A, Milgrom ML. Bilateral Sequential Lung and Simultaneous Pancreas Transplant: A New Approach for the Recipient with Cystic Fibrosis. J Cyst Fibros. 2008 Jul; 7(4):280-4.
  38. Vianna RM, Fridell JA, Mangus RS, Hollinger EF, Matiosky A, Tector AJ. Safe Inclusion of the Entire Pancreas as a Component of the Multivisceral Graft. Transplantation. 2008 Jul 15; 86(1):114-6.
  39. Mangus RS, Tector AJ, Fridell JA, Kazimi M, Hollinger E, Vianna RM. Comparison of Histidine-Tryptophan-Ketoglutarate Solution and University of Wisconsin Solution in Intestinal and Multivisceral Transplantation. Transplantation. 2008 Jul 27; 86(2):298-302.
  40. Vianna RM, Mangus RS, Fridell JA, Kazimi M, Hollinger E, Tector AJ. Initiation of an Intestinal Transplant Program: The Indiana Experience.  Transplantation.  85(12): 1784-90, 2008 Jun 27.
  41. Mangus, RS, Fridell JA, Vianna RM, Cooper AB, Jones DT, Tector AJ.  Use of the Piggyback Hepatectomy Techniques in Liver Transplant Recipients with Hepatocellular Carcinoma.  Transplantation.  85(10): 1496-9, 2008 May 27.
  42. Fridell JA, Wozniak TC, Reynolds JM, Powelson JA, Hollinger EF, Duncan MW, Sannuti A, Milgrom ML.  Bilateral Sequential Lung and Simultaneous Pancreas Transplant: a new Approach for the Recipient with Cystic Fibrosis. Transplantation Proceedings 40(2): 494-7, 2008 Mar.
  43. Vianna RM, Mangus RS, Fridell JA, Weigman S, Kazimi M, Tector AJ, Induction Immunosuppression with thymoglobulin and rituxumab in Interstinal and Multivisceral Transplantation.  Transplantation. 85(9):1290-3, 2008 May 15
  44. Vianna, RM, Fridell JA, Mangus RS, Hollinger EF, Matiosky A, Tector AJ.  Safe inclusion of the Entire Pancreas as a component of the Multivisceral Graft.  Transplantation. 86(1): 114-6, 2008 Jul 15.
  45. Mangus RS, Tector AJ, Fridell JA, Kazimi M, Hollinger EF, Vianna, RM.  Comparison of Histidine-Trytophan-Ketoglutarate  Solution and University of Wisconsin Solution in Intestinal and Multivisceral Transplantation.  Transplantation 86(2): 298-203, 2008 Jul 27.
  46. Fridell JA, Vianna R, Mangus RS, Kazimi M, Hollinger ER, Tector AJ.  Addition of a total Pancreatectomy and Pancreas Transplantation in a Liver Transplant Recipient with Intraductal Papillary Mucinous Neoplasm of the Pancreas.  Clinical Transplantation 22(5):6 81-4, 2008 Sep-Oct.
  47. Hollinger EF, Powelson JA, Mangus RS, Kazimi MM, Taber, TE, Goble ML, Fridell JA.  Immediate Re-transplantation for Pancreas Allograft Thrombosis.  American Journal of Transplantation 9(4): 740-5, 2009 Apr.
  48. Mangus RS, Fridell JA, Vianna RM, Kwo PY, Chestovich P, Milgrom ML, Kazimi M, Hollinger EF, Read JT, Tector AJ.  No Difference in Clinical Transplant Outcomes for local and Imported Liver Allografts.  Liver Transplantation 15(6): 640-7, 2009 Jun.
  49. Fridell  JA, Mangus RS, Tector AJ.  Clinical Experience with Histidine-tryptophan-Ketoglutarate Solution in Abdominal Organ Preservation:  A Review of Recent Literature.  Clinical Transplantation, 23 (3):305-12, 2009 Jun-Jul.
  50. Fridell JA, Mangus RS, Hollinger ER, Taber TE, Goble ML, Mohler E, Milgrom ML, Powelson JA.  The Case for Pancreas after Kidney Transplantation.  Clinical Transplantation 23(4):447-53, 2009 Aug-Sept.
  51. Fridell JA, Mangus RS, Hollinger EF, Milgrom ML, Taber TE, Mohler E, Good J, Goble ML, Powelson JA.  No Difference in Transplant Outcomes for Local and Import Pancreas Allografts.  Transplantation 88(5):723-8, 2009 Sept 15.
  52.  Fridell JA, Tector AJ, Mangus RS, Kazimi MM, Hollinger EF, Vianna RM.  A New Vascular Approach to the Modified Graft Procurement.  Clinical Transplantation 23 (6):784-7, 2009 Nov-Dec
  53. Fridell  JA, Mangus, RS, Powelson JA.  Histidine-Tryptophan-Ketoglutarate for Pancreas Allograft Preservation:  The Indiana University Experience.  American Journal of Transplantation 10(5):1284-9, 2010 May.
  54. Fridell  JA, Rogers J, Stratta  RJ.  The pancreas allograft donor:  current status, controversies, and challenges for the future.  Clinical Transplantation 24 (4): 443-49, 2010 Jul
  55. Kubal S, Fridell JA, Powelson JA, Taber TE, Goble ML.  Simultaneous pancreas and kidney transplantation with concurrent allograft nephrectomy for recipients with prior renal transplants lost to BK virus nephrology:  two case reports.  Transplantation Proceedings.42 (6):2009-10, 2010 Jul-Aug
  56. Mujtaba M, Taber T, Goggins WC, Yaqub M, Mishler D, Milgrom ML, Fridell JA, Lobashevsky A, Powelson JA, Sharfuddin A.  Early Steriod Withdrawal in Repeat Kidney Transplantation.  Clin J Am Soc Nephrol. Clin J Am Soc Nephrol. 2011 Feb; 6(204-11. Epub 2010 Nov 4.
  57. Fridell, JA, Mangus, RS, Powelson, JA. Organ preservation solutions for whole organ pancreas transplantation. Current Opinion in Organ Transplantation: 16 (1 ): 116–122. February 2011
  58. Fridell JA, Mangus RS, Mull AB, Taber TE, Sanders CE, Slisher RC, Goble ML, Powelson JA.  Early re-exploration for suspected thrombosis after pancreas transplantation.  Transplantation 91 (8): 902-7, 2011 Apr 27, 2011
  59. Fridell JA, Powelson JA, Sanders CE, Ciancio G, Burke GW 3rd, Stratta RJ.  Preparation of the pancreas allograft for transplantation.  Clinical Transplantation. 25 (2): E103-12, 2011 Mar-Apr.
  60. Fridell, JA, Mangus RS, Taber TE, Goble ML, Milgrom ML, Good J, Vetor R, Powelson JA.  Growth of a Nation Part II:  Impact of recipient obesity on whole organ pancreas transplantation.  Clinical Transplantation 2011:  25:  E366-E374.
  61. Fridell, JA, Mangus RS, Taber TE, Goble ML, Milgrom ML, Good, J, Vetor R, Powelson JA.  Growth of a Nation Part 1:  Impact of organ donor obesity on whole-organ pancreas transplantation.  Clinical Transplantation 2011:  25:  E225-E232
  62. Porubsky M, Powelson JA, Selzer DJ, Mujtaba MA, Taber T, Carnes KL, Fridell JA. Pancreas transplantation after bariatric surgery. Clinical Transplantation. 2012 Jan;26(1):E1-6. Nov 4.
  63. Fridell, JA, Johnson MS, Goggins WC, Beduschi T, Mujtaba MA, Goble ML, Powelson JA. Vascular catastrophes following pancreas transplantation: an evolution in strategy at a single center.  Clinical Transplantation. 2012 Jan;26(1):164-72.
  64. Vianna R, Mangus RS, Kubal SA, Fridell JA, Beduschi T, Tector AJ. Multivisceral Transplantation for Diffuse Porto-Mesenteric Thrombosis. In press Annals of Surgery 2012
  65. Mangus R, Fridell J, Vianna R, Kwo P, Chen J, Tector A.  Immunosuppression induction with rabbit anti-thymocyte globulin with or without rituximab in 1000 liver transplant patients with long-term follow-up.  Liver Transplantation. 18(7):786-95, 2012 July.
  66. Kandula P, Fridell J, Taber T, Sharfuddin A, Yaqub S, Phillips C, Chen J, Mujtaba M.  Impact of tacrolimus-sirolimus maintenance immunosuppression on proteinuria and kidney function in pancreas transplant alone recipients.  Transplantation. 94(9):940-6, 2012 Nov 15
  67. Fridell J, Mangus R, Powelson J, Vianna R, Tector A.
  68. Fridell JA, Mangus RS, Powelson JA, Vianna RM, Tector AJ. “Outcomes of pancreas allografts procured simultaneously with an isolated intestine allograft: Single center and national data”. In press Transplantation 2012.
  69. Mujtaba M, Fridell JA, Sharfuddin A, Kandula P. Yaqub M, Taber T.  BK Virus in Nephropathy in simultaneous pancreas kidney transplant:  A potentially preventable cause of Kidney Allograft Loss.  Clin Transplant.  2012  DOI: 10.1111/j.1399-0012.2012.01599.x.
  70. Ashesh A, Mangus R, Powelson J, Kannan P, Taber T, Goble M, Fridell J.  Impact of recipient age on whole organ pancreas transplantation.  Clin Transplant 2012 DOI:10.1111/ctr.12047

Department of Surgery | 545 Barnhill Drive, Emerson Hall 203, Indianapolis, In 46202 | Phone: (317) 274-5771