Michele T. Yip-Schneider, PhD
Associate Research Professor of Surgery
Specialty: General Surgery
Michele Yip-Schneider received her PhD in Biochemistry from the University of California, Davis. Following post-doctoral training at the University of California, Los Angeles and Indiana University School of Medicine, she joined the Department of Surgery faculty at Indiana University School of Medicine in 2001. Her training in molecular biology and human disease provides the necessary background and expertise to pursue current translational studies in pancreatic cancer.
My research interests include understanding how dysregulated cellular signaling pathways drive pancreatic tumorigenesis. Specifically, the pathway regulated by the transcription factor nuclear factor-kappaB (NF-kB) has been demonstrated to play a critical role in the development and progression of pancreatic cancer. Thus, we have been investigating the NF-kB pathway as a promising target. For these translational studies, our laboratory employs several pre-clinical animal models (standard flank tumor and patient pancreatic tumor tissue xenografts, carcinogen-induced hamster model, genetically engineered mice) to evaluate the chemopreventative and chemotherapeutic potential of various agents for the treatment of pancreatic cancer. In addition to identifying novel therapeutics, we are also interested in identifying potential biomarkers that can aid in the differential diagnosis of pancreatic lesions. The development of such biomarkers will facilitate risk stratification of high risk patients and thereby promote early detection and prevention.