Nicholas J. Zyromski, MD

Associate Professor of Surgery

Specialty: General Surgery

Residency: Medical College of Ohio

Fellowship: Mayo Clinic (Gastrointestinal), Indiana University School of Medicine (Hepatobiliary)


Dr. Zyromski received medical school and general surgery training at the Medical College of Ohio in Toledo, Ohio.  He served as an NIH research fellow at the Mayo Clinic in Rochester, Minnesota.  He was the first clinical hepatopancreatobiliary surgery fellow at Indiana University (2005), and is currently the Indinana University HPB Surgery Fellowship Program Director.


Dr. Zyromski’s principal clinical interest is in pancreatic disease; his basic and translational research interest focuses on the inflammatory response of acute pancreatitis as well as the influence of obesity and adipose tissue on pancreatic diseases – pancreatic cancer and acute pancreatitis.


IU Health Physicians


IU Health Methodist/IU Health University

Location Information

IU Health University Hospital, Surgery OP Clinic

550 N. University Blvd., Ste 1295

Indianapolis, IN 46202

Clinical Interests


Accepting New Patients

Schedule an Appointment  Clinical Trials

Clinical Research Interests: Pancreatitis, pancreatic disease, gastrointestinal surgery

Basic Research Interests: Pancreatitis, pancreatic neoplasia

Research Page


  1. Hoff HF, Zyromski N, Armstrong D, O’Neil J.  Aggregation as well as chemical modification of LDL during oxidation is responsible for poor processing in macrophages. J Lipid Res.  1993 Nov;34(11):1919-29. (PMID: 8263416)
  2. Zyromski NJ, Haidenberg J, Sarr MG.  Necrotizing pancreatitis caused by pancreatic ductal adenocarcinoma. Pancreas. 2001 May;22(4):431-2.  (PMID: 11345146)
  3. Kendrick ML, Meile T, Zyromski NJ, Tanaka T, Sarr, MG.  Extrinsic neural innervation mediates absorption of water and electrolytes in canine proximal colon in vivo. J Surg Res. 2001 May 1;97(1):76-80.  (PMID: 11319884)
  4. Tanaka T, Kendrick ML, Zyromski NJ, Meile T, Sarr MG.  Vagal innervation modulates motor pattern but not initiation of canine gastric migrating motor complex.  Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G283-92  (PMID: 11408282)
  5. Zyromski NJ, Duenes JA, Kendrick ML, Balsiger BM, Farrugia G, Sarr MG.  Mechanism mediating nitric oxide-induced inhibition in human jejuna longitudinal smooth muscle. Surgery. 2001 Sep;130(3):489-96.  (PMID: 11562674)
  6. Sarr MG, Libsch KD, Duininck TM, NJ Zyromski.  Bariatric Surgery:  the role of the surgeon in the treatment of obesity.  The Specialist Forum 7 (2001) 30-40.
  7. Duininck TM, Libsch KD, Zyromski NJ.  Enlarging Neck Mass in an Elderly Female.  Contemporary Surgery 57(10): 512-14 (2001).
  8. Zyromski NJ, Kendrick ML, Nagorney DM, Grant CS, Donohue JH, Farnell MB, Thompson GB, Farley DR, Sarr MG.  Duodenal carcinoid tumors: how aggressive should we be?  J Gastrointest Surg. 2001 Nov-Dec;5(6):588-93.  (PMID: 12086896)
  9. Libsch KD, Zyromski NJ, Tanaka T, Kendrick ML, Haidenberg J, Peia D, Worni M, Duenes JA, Kost LJ, Sarr MG.  Role of extrinsic innervation in jejunal absorptive adaptation to subtotal small bowel resection: a model of segmental small bowel transplantation.  J Gastrointest Surg. 2002 Mar-Apr;6(2):240-7.  (PMID: 11992810)
  10. Libsch KD, Zyromski NJ, Duininck TM, Sarr MG.  Bariatric Surgery:  One answer to an increasing problem.  Patient Care 2002; 36(5): 68-76.
  11. Kendrick ML, Zyromski NJ, Tanaka T, Duenes JA, Libsch K, Sarr MG. Postprandial absorptive augmentation of water and electrolytes in the colon requires intraluminal glucose. J Gastrointest Surg.  2002 May-Jun;6(3):310-5.  (PMID: 12022980)
  12. Zyromski NJ, Duenes JA, Kendrick ML, Libsch KD, Seiler R, Tanaka T, Sarr MG.  Differential adrenergic response to extrinsic denervation in canine longitudinal jejuna and ileal smooth muscle.  J Gastrointest Surg. 2002 May-Jun;6(3):418-25.  (PMID: 12022995)
  13. Kendrick ML, Meile T, Zyromski NJ, Tanaka T, Libsch KD, Sarr MG.  Extrinsic denervation causes a transient proabsorptive adrenergic hypersensitivity in the canine proximal colon.  Dig Dis Sci. 2002 Aug;47(8):1752-7.  (PMID: 12184526)
  14. Tanaka T, Zyromski NJ, Libsch KD, Kendrick ML, Sarr MG.  Canine ileal motor activity after a model of jejunoileal autotransplantation. Ann Surg. 2003 Feb;237(2):192-200.  (PMID: 12560777)
  15. Duininck TM, Libsch KD, Zyromski NJ, Ueno T, Sarr MG.  Small bowel extrinsic denervation does not alter water and electrolyte absorption from the colon in the fasting or early postprandial state.  J Gastrointest Surg. 2003 Mar-Apr;7(3):347-53.  (PMID: 12654559)
  16. Zyromski N, Murr MM.  Evolving concepts in the pathophysiology of acute pancreatitis.  Surgery. 2003 Mar;133(3):235-7.  (PMID: 12660632)
  17. Balsiger BM, He CL, Zyromski NJ, Sarr MG.  Neuronal adrenergic and muscular cholinergic contractile hypersensitivity in canine jejunum after extrinsic denervation.  J Gastrointest Surg. 2003 May-Jun;7(4):572-82.  (PMID: 12763419)
  18. Zyromski NJ, Staren ED, Merrick HW.  Surgical residents’ perception of the objective structured clinical examination (OSCE).  Curr Surg. 2003 Sep-Oct;60(5); 533-7.  (PMID: 14972220)
  19. Chiba T, Sarr MG, Kendrick ML, Meile T, Zyromski NJ, Tanaka T, Kost LJ, Bharucha AE, Phillips SF.  Limitations of implantable, miniature ultrasonic transducers to measure wall movement in the canine jejunum. J Surg Res. 2004 Feb;116(2):219-26.  (PMID: 15013359)
  20. Zyromski NJ, Camp, CM.  Splenic injury:  a rare complication of endoscopic retrograde cholangiopancreatography.  Am Surg.  2004 Aug;70(8):737-9.  (PMID: 15328812)
  21. Zyromski NJ, Duenes, JA, Sarr, MG.  Inhibition by nitric oxide and nonadrenergic, noncholinergic (NANC) nerves is preserved in a canine model of extrinsic denervation: implications for small bowel transplantation.  Surgery. 2005 Nov;138(5):905-12.  (PMID: 16291392)
  22. Zyromski NJ, Lillemoe, KD.  Current management of biliary leaks.  Adv Surg. 2006;40:21-46.  (PMID: 17163093)
  23. Howard TJ, Krug JE, Yu J, Zyromski NJ, Schmidt CM, Jacobson LE, Madura JA, Wiebke EA, Lillemoe KD.  A margin-negative R0 resection accomplished with minimal postoperative complications is the surgeon’s contribution to long-term survival in pancreatic cancer.  J Gastrointest Surg. 2006 Dec;10(10):1338-45.  (PMID: 17175452)
  24. Howard TJ, Patel JB, Zyromski N, Sandrasegaran K, Yu J, Nakeeb A, Pitt HA, Lillemoe KD.  Declining morbidity and mortality rates in the surgical management of pancreatic necrosis. J Gastrointest Surg.  2007 Jan;11(1):43-9.  (PMID: 17390185)
  25. Smith BM, Zyromski NJ, Allison DC.  Community-acquired methacillin-resistant staphylococcus aureus liver abscess requiring resection.  Surgery. 2007 Jan;141(1):110-1.  (PMID: 17188175)
  26. Zyromski NJ, Duenes JA, Kendrick ML, Farrugia G, Sarr MG.  Mechanism of Nitric Oxide inhibition in human jejunal smooth muscle. Surgical Forum vol LI, 11-13; 2000
  27. Zyromski NJ, Duenes JA, Kendrick ML, Libsch KD, Tanaka T, Sarr MG.  Nitric oxide and non-adrenergic, non-cholinergic (NANC) inhibition are preserved after a model of small bowel transplantation.  Surgical Forum, vol LII 2001
  28. Zyromski NJ, Purtill, MA. Large caliber bullet lodged in the thoracic spinal column. J Trauma 2006; 60(2): 457.  (PMID: 16508518)
  29. Zyromski NJ, Tatro SJ, Stark ME.  A striking foreign body. J Emer Med 2006 30(3); 349-350.  (PMID: 16677992)
  30. Howard TJ, Zyromski NJ.  Pancreatoduodenectomy for cancer:  technical aspects of the retroperitoneal soft tissue dissection to maximize a negative surgical margin (video) Society for Surgery of the Alimentary Tract, May 19-24, 2007, Washington, D.C.
  31. Zyromski NJ.  Upper rectus rigidity predicts acute appendicitis. Contemporary Surgery 2007; 63(11):573.
  32. Zyromski NJ, Lillemoe KD.  Essentials of Surgical Oncology (book review). J Surg Res, e-published ahead of print,  31 January 2008.
  33. Zyromski NJ.  The Life and Times of Allen Oldfather Whipple:  The Missionary and the Surgeon (book review).  J Surg Res, 1 January 2008.
  34. Howard TJ, Zyromski NJ, Lavu H.  Technical apects of duodenal preserving pancreatic head resections (DPPHR):  The Frey and Beger Operations (video) Society for Surgery of the Alimentary Tract, May 30-June 3, 2009  Chicago, IL.
  35. Zyromski NJ.  Necrotizing pancreatitis 2010: an unfinished odyssey.  Ann Surg. 2010 May:251(5) 794-5. (PMID 20195831)
  36. Ball CG, Correa-Gallego C, Howard TJ, Zyromski NJ, Lillemoe KD.  Damage control principles for pancreatic surgery. J Gastrointest Surg. 2010 Oct;14(10):1632-3 (PMID 20714938)
  37. Zyromski NJ. Commentary on Human bone marrow-derived clonal mesenchymal stem cells inhibit inflammation and reduce acute pancreatitis in rats (Gastroenterology 2011; 140:998-1008). Selected Readings in General Surgery 2011.
  38. Zyromski NJ. Commentary on: Long term outcomes of endoscopic vs surgical drainage of the pancreatic duct in patients with chronic pancreatitis (Gastroenterology 2011;141:1690-5). Selected Readings in General Surgery 2011.
  39. Zyromski NJ. Commentary on: Multidrug strategies are effective in the treatment of severe experimental pancreatitis (Surgery 2012; 151: 372-81). Selected Readings in General Surgery 2012.
  40. Zyromski NJ. Autoimmune Pancreatitis (AIP) masquerading as pancreatic cancer: cutting is not a crime…for now.  Dig Dis Sci 2012 Jun 26. Epub (PMID: 22732835).
  41. Zyromski NJ. Novel treatments for acute pancreatitis: possibility or pipe dream?  Invited commentary on “Protective effect of ethyl pyruvate on pancreas injury in rats with severe acute pancreatitis. J Surg Res 2012 Jul 20 epub (PMID: 22831563).
  42. Zyromski NJ. Commentery on: Surgery for Chronic Pancreatitis decreases the risk for pancreatic cancer (Surgery 2013; 153:357-64), Selected Readings in General Surgery 2013.

Department of Surgery | 545 Barnhill Drive, Emerson Hall 203, Indianapolis, In 46202 | Phone: (317) 274-5771