Andrew C. Eppstein, MD

Assistant Professor of Clinical Surgery

Specialty: General Surgery

Residency: Indiana University School of Medicine

Fellowship: University of Cincinnatti College of Medicine (Minimally Invasive Surgery)


Andrew C. Eppstein, MD, FACS, joined the Indiana University School of Medicine as full-time faculty at the Richard L. Roudebush VA Medical Center in July of 2009.  He received his MD degree at Case Western University School of Medicine in Cleveland, Ohio, and completed his internship and residency in general surgery at Indiana University School of Medicine.  During his residency, he researched inhibition of cellular pathways in the pediatric cancer neuroblastoma.  After residency he completed a fellowship in minimally invasive gastrointestinal and bariatric surgery at the University of Cincinnati College of Medicine.  He was recruited back to IU to enhance the laparoscopic program at the Roudebush VA Medical Center, a tertiary care hospital that serves the veteran populations of Indiana and Central and Eastern Illinois.  His major clinical interests are laparoscopic hernia repair, abdominal wall reconstruction, laparoscopic antireflux procedures, and gastric malignancies.  He is a Fellow of the American College of Surgeons and a member of the Society of Gastrointestinal Endoscopic Surgeons (SAGES), the Society of Laparoendoscopic Surgeons (SLS), and the Association of VA Surgeons (AVAS).

Clinical Research Interests: Minimally invasive general surgery


  1. Sakamoto B, Gwirtz K, and Eppstein AC.  A novel perioperative technique for the identification and localization of the ilioinguinal nerve for neurectomy. J Clin Anes 2013 Mar 21 (online, in press)
  2. Eppstein AC and Munshi IA.  General surgery resident attitudes toward the VA: reaching out to the next generation.  Oral presentation, Association of VA Surgeons 34th Annual Surgical Symposium, Indianapolis, IN, May 9-11, 2010.
  3. Eppstein AC, “Chapter 2: Hernia.”  Tevar AD, Pritts T, ed.  Surgery Review Illustrated, 2nd ed.  New York: McGraw-Hill (in press).
  4. Eppstein AC, Gatta P, Martin Hawver LM, Broderick TJ.  Emergent laparoscopic surgery for perforated ulcers and peritonitis: a case review.  Poster presentation, Society of American Gastrointestinal Endoscopic Surgeons (SAGES) 2009 Scientific Session, Phoenix, AZ, April 23-25, 2009.
  5. Sandoval JA, Eppstein AC, Hoelz DJ, Klein PJ, Linebarger JH, Turner KE, Rescorla FJ, Hickey RJ, Malkas LH, Schmidt CM.  Proteomic analysis of neuroblastoma subtypes in response to mitogen-activated protein kinase inhibition: profiling multiple targets of cancer kinase signaling.  J Surg Res. 2006 Jul 1; 134(1):61-7.
  6. Eppstein AC, Sandoval JA, Klein PJ, Woodruff HA, Grosfeld JL, Hickey RJ, Malkas LH, Schmidt CM.  Differential sensitivity of chemoresistant neuroblastoma subtypes to MAPK-targeted treatment correlates with ERK, p53 expression, and signaling response to U0126.  J Pediatr Surg. 2006 Jan; 41(1):252-9.  Poster presentation, American Pediatric Surgical Association annual meeting, Phoenix, AZ, May 29-June 1, 2005.
  7. Eppstein AC, Sandoval JA, Klein PJ, Woodruff HA, Grosfeld JL, Hickey RJ, Malkas LH, Schmidt CM.  Differences in MAP kinase signaling responses to MEK inhibition in three distinct neuroblastoma cell types.  Poster presentation, Association for Cancer Research, Anaheim, CA, April 16-20, 2005.
  8. Selzer D and Eppstein AC, “Chapter 41: Minimally Invasive Surgery and Bariatrics.”  Tevar AD, Azuaje RE, Micon LT, ed.  Surgery Review Illustrated.  New York: McGraw-Hill, 2005.
  9. Khan S, Eppstein AC, Anderson GK, Dengal MK, Eggenberger JC, Lee CS, Szilagy EJ, Margolin DA.  Acute diverticulitis in heart- and lung transplant patients.  Transpl Int 2001; 14(1):12-5.
  10. Khan S, Anderson GK, Eppstein AC, Eggenberger JC, Margolin DA.  Ulcerative colitis and colonic lymphoma: a theoretical link.  Am Surg. 2001 Jul; 67(7):654-6.
  11. Salles-Cunha SX, Scissons R, Beebe HG, Eppstein A.  Carotid ultrasound imaging: comparison of NASCET and ECST measurements to predict arteriographic resultsPresented at the Society of Vascular Technology’s 20th Annual Conference, San Francisco, CA, July 23-27, 1997.
  12. Beebe HG, Salles-Cunha SX, Scissons R, Eppstein A, Dosick SM, Whalen RC, Gale SS, Pigott JP, Vitti MJ.  Cost effectiveness of infrainguinal bypass graft surveillance:  short versus long protocols.  Presented at the North American Chapter of the International Society for Cardiovascular Surgery, New Orleans, LA, June 13, 1995.

Department of Surgery | 545 Barnhill Drive, Emerson Hall 203, Indianapolis, In 46202 | Phone: (317) 274-5771