Specialty: Cardiac Surgery in basic research

Medical School: West China University of Medical Sciences, China

Residency: Department of Pediatrics, The Children's Hospital of Chengdu City, China

Fellowships: Pediatric Hematology, Department of Pediatrics, 2nd University Hospital, West China University of Medical Sciences, China

Basic Research Interests: The research activities in my lab include investigation of the mechanisms involved in ischemic heart disease and development of effective pharmacological/molecular interventions based on sex hormones or stem/progenitor cell therapy for the treatment of myocardial ischemia. Our current interests are:

1. Sex differences in myocardial responses to acute injury
2. Stem cell-based therapy in myocardial ischemia
3. Epigenetic regulation in stem cell function
   

Publications

1. Wang M *, Qing Yu, Lina Wang, Gu H. (2013) Distinct patterns of histone modifications at cardiac-specific gene promoters between cardiac stem cells and mesenchymal stem cell. Am J Physiol Cell Physiol. 2013 Apr 3 [Epub ahead of print]  *corresponding author
2. Huang C, Gu H, Yu Q, Manukyan MC, Poynter JA, Wang M*. (2011) Sca-1+ cardiac stem cells mediate acute cardioprotection via paracrine factor SDF-1 following myocardial ischemia/reperfusion. PLoS ONE, 6(12):e29246. PMCID: PMC3240662  *corresponding author
3. Huang C, Gu H, Zhang W, Manukyan MC, Shou W, Wang M*. (2011) SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury. Am J Physiol Heart Circ Physiol. 301(4): H1496-505. PMCID: PMC3197365   *corresponding author
4. Huang C, Gu H, Wang Y, Wang M*. (2011) Estrogen-induced SDF-1 production is mediated by estrogen receptor α in female hearts following acute ischemia and reperfusion. Surgery, 150(2): 197-203. PMCID: PMC3148411 *corresponding author
5. Huang C, Gu H, Zhang W, Herrmann JL, Wang M*. (2010) Testosterone-downregulated Akt pathway during cardiac ischemia/reperfusion: a mechanism involving Bad, Bcl-2 and FOXO3a. J Surg Res.164(1):e1-11. PMCID: PMC2957547  *corresponding author
6. Wang M, Tan J, Wang Y, Meldrum KK, Dinarello CA, Meldrum DR. (2009) IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. Proc Natl Acad Sci U S A. Oct. 106(41): 17499-504. PMCID: PMC2752405
7. Wang M*, Wang Y, Weil B, Aaron A, Herrmann J, Tan J, Kelly M, Meldrum DR. (2009) Estrogen receptor β mediates increased activation of PI3K/Akt signaling and improved myocardial function in female hearts following acute ischemia.  Am J Physiol Regul Integr Comp Physiol. 296(4): R972-978. PMCID: PMC2698598 *corresponding author
8. Wang M, Wang Y, Aaron A, Tan J, Weil B, Herrmann J, Meldrum DR. (2009) Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion. Surgery, 146(2): 138-44. PMCID: PMC2771912
9. Wang M, Tan J, Coffey A, Fehrenbacher J, Weil BR, Meldrum DR. (2009) Signal transducer and activator of transcription 3-stimulated hypoxia inducible factor-1α mediates estrogen receptor-α-induced mesenchymal stem cell vascular endothelial growth factor production.  J Thorac Cardiovasc Surg. 138(1):163-71, 171.e1. PMCID: PMC2929584
10. Wang M, Crisostomo PR, Markel TA, Wang Y, Meldrum DR. (2008) Mechanisms of sex differences in TNFR2 mediated cardioprotection. Circulation, 118 (14S):S38-45. PMCID: PMC2655136
11. Sando IC, Wang Y, Crisostomo PR, Markel TA, Sharma R, Erwin GS, Guzman MJ, Meldrum DR, Wang M*. (2008) Females Exhibit Relative Resistance to Depressive Effects of Tumor Necrosis-Factor-alpha on the Myocardium. J Surg Res. 150(1): 92-9. PMCID: PMC2586947  *corresponding author
12. Wang M, Crisostomo PR, Markel TA, Wang Y, Lillemoe KD, Meldrum DR. (2008) Estrogen receptor beta mediates acute myocardial protection following ischemia.  Surgery,144(2): 233-8
13. Wang M, Markel T, Crisostomo P, Herring C, Meldrum KK, Lillemoe KD, Meldrum DR. (2007) Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6, but not p38 MAPK or IL-1 beta. Am J Physiol Heart Circ Physiol. 292(4): H1694-9
14. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY, Meldrum DR. (2007) Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Am J Physiol Endocrinol Metab, 293(3):E872-7
15. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY, Meldrum DR. (2007) Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling. Am J Physiol Regul Integr Comp Physiol, 293(5):R1893-7
16. Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY, Meldrum DR. (2007) STAT3 mediates bone marrow mesenchymal stem cell VEGF production. J Mol Cell Cardiol, 42(6): 1009-15. PMCID: PMC1993849
17. Wang M, Tsai BM, Crisostomo P, Meldrum DR. (2006) Tumor necrosis factor receptor 1 signaling resistance in female myocardium during ischemia.  Circulation. 114 (S): I282-9
18. Wang M, Tsai BM, Reiger KM, Brown JW, Meldrum DR. (2006) 17-b-estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia.  J Mol Cell Cardiol. 40(2): 205-12
19. Wang M, Crisostomo P, Wairiuko GM, Meldrum DR. (2006) Estrogen receptor alpha mediates acute myocardial protection in females.  Am J Physiol Heart Circ Physiol. 290(6): H2204-9
20. Wang M, Tsai BM, Crisostomo P, Meldrum DR. (2006) Pretreatment with adult progenitor cells improves recovery and decreases native myocardial proinflammatory signaling after ischemia. Shock. 25(5):454-9
21. Wang M, Crisostomo P, Herring C, Meldrum KK, Meldrum DR. (2006) Human progenitor cells from bone marrow or adipose tissue produce VEGF, HGF and IGF-1 in response to TNF by a p38 MAPK dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 291(4): R880-4
22. Wang M, Sankula R, Tsai B, Meldrum KK, Turrentine M, March KL, Brown JW, Dinarello CA, Meldrum DR. (2004) p38 MAPK mediates myocardial proinflammatory cytokine production and endotoxin-induced contractile suppression. Shock, 21(2): 170-174
23. Wang M, Baker L, Tsai BM, Meldrum KK and Meldrum DR. (2005) Sex differences in the myocardial inflammatory response following ischemia/reperfusion injury. Am. J. Physiology Endocrinol Metab. 288(2): E321-6
24. Wang M, Tsai BM, Kher A, Baker LB,Wairiuko GM and Meldrum DR. (2005) Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am. J. Physiology Heart Circ Physiol, 288(1): H221-6
25. Wang M, Tsai BM, Turrentine MW, Mahomed Y, Brown JW, Meldrum DR. (2005) p38 MAPK mediates both death signaling and functional depression in the heart.  Ann Thorac Surg. 80(6): 2235-41
26. Wang M, Meng X, Tsai B, Wang JF, Turrentine M, Brown JW, Meldrum DR. (2004) Preconditioning upregulates the soluble TNF receptor I response to endotoxin. J. Surgical Research 121(1): 20-24